TrialChat: Co-Designing Agentic AI for Alzheimer's Clinical Trial Engagement

Older adults remain underrepresented in Alzheimer's disease and related dementias (ADRD) clinical trials despite bearing much of the disease burden. TrialChat is an AI-powered digital navigator addressing this gap through a conversational chatbot powered by an agentic AI framework and machine learning-based trial matching algorithm. Developed by S-3 Research LLC and CSU Fullerton, and supported by the U.S. National Institute on Aging under the NIH AITC program, TrialChat delivers personalized education and clinical trial recommendations via web and mobile platforms. What distinguishes TrialChat is its co-design approach: older adults and caregivers directly shape its language, flow, and features, elevating voices often overlooked in digital health while designed for commercialization and real-world application. This session shares TrialChat's architecture, early insights, and lessons for scaling inclusive, AI-enabled clinical trial engagement tools across health systems.